TAp63 induces senescence and suppresses tumorigenesis in vivo

  title={TAp63 induces senescence and suppresses tumorigenesis in vivo},
  author={Xuecui Guo and William M. Keyes and Cristian Papazoglu and Johannes Zuber and Wangzhi Li and Scott W Lowe and Hannes Vogel and Alea A. Mills},
  journal={Nature Cell Biology},
p63 is distinct from its homologue p53 in that its role as a tumour suppressor is controversial, an issue complicated by the existence of two classes of p63 isoforms. Here we show that TAp63 isoforms are robust mediators of senescence that inhibit tumorigenesis in vivo. Whereas gain of TAp63 induces senescence, loss of p63 enhances sarcoma development in mice lacking p53. Using a new TAp63-specific conditional mouse model, we demonstrate that TAp63 isoforms are essential for Ras-induced… CONTINUE READING