TAZ, a Transcriptional Modulator of Mesenchymal Stem Cell Differentiation

@article{Hong2005TAZAT,
  title={TAZ, a Transcriptional Modulator of Mesenchymal Stem Cell Differentiation},
  author={Jeong-Ho Hong and Eun Sook Hwang and Michael T. McManus and Adam H Amsterdam and Yu Tian and Ralitsa Kalmukova and Elisabetta Mueller and Thomas L. Benjamin and Bruce M Spiegelman and Phillip A. Sharp and Nancy Hopkins and Michael B. Yaffe},
  journal={Science},
  year={2005},
  volume={309},
  pages={1074 - 1078}
}
Mesenchymal stem cells (MSCs) are a pluripotent cell type that can differentiate into several distinct lineages. Two key transcription factors, Runx2 and peroxisome proliferator–activated receptor γ (PPARγ), drive MSCs to differentiate into either osteoblasts or adipocytes, respectively. How these two transcription factors are regulated in order to specify these alternate cell fates remains a pivotal question. Here we report that a 14-3-3–binding protein, TAZ (transcriptional coactivator with… Expand
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TLDR
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Osteoblastogenic effects of dexamethasone through upregulation of TAZ expression in rat mesenchymal stem cells
TLDR
It is found that DEX at the concentration of 10(-8)M enhanced calcium deposition, TAZ, bone morphogenetic protein 2 (BMP-2) and alkaline phosphatase (ALP) expression during osteoblastic differentiation, supporting the notion that TAZ is a convergence point of two signaling pathways, B MP-2 signaling pathway and Wnt-beta-catenin signaling pathway. Expand
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Mesenchymal stem cells (MSCs) can be isolated from bone marrow and can differentiate in a variety of cell types, including osteoblasts, adipocytes, chondrocytes, myoblasts, hepatocytes, and neuralExpand
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