TAZ, a Transcriptional Modulator of Mesenchymal Stem Cell Differentiation

  title={TAZ, a Transcriptional Modulator of Mesenchymal Stem Cell Differentiation},
  author={Jeong-Ho Hong and Eun Sook Hwang and Michael T. McManus and Adam Amsterdam and Yu Tian and Ralitsa Kalmukova and Elisabetta Mueller and Thomas L. Benjamin and Bruce M Spiegelman and Phillip A. Sharp and Nancy Hopkins and Michael B. Yaffe},
  pages={1074 - 1078}
Mesenchymal stem cells (MSCs) are a pluripotent cell type that can differentiate into several distinct lineages. Two key transcription factors, Runx2 and peroxisome proliferator–activated receptor γ (PPARγ), drive MSCs to differentiate into either osteoblasts or adipocytes, respectively. How these two transcription factors are regulated in order to specify these alternate cell fates remains a pivotal question. Here we report that a 14-3-3–binding protein, TAZ (transcriptional coactivator with… 
TAZ: A β-Catenin-like Molecule that Regulates Mesenchymal Stem Cell Differentiation
It is proposed that TAZ, as well as a highly related molecule YAP, are functionally, though not structurally, similar to β-catenin and integrate extracellular, membrane, and cytoskeletal-derived signals to influence mesenchymal stem cell fate.
Key transcription factors in the differentiation of mesenchymal stem cells.
Molecular switching of osteoblastogenesis versus adipogenesis: implications for targeted therapies
Two signaling cascades promote osteoblastic differentiation from MSC through two distinct modes of PPar-γ transrepression, which switch the cell fate decision from adipocytes to osteoblasts by suppressing the transactivation function of PPAR-γ.
Regulation of Mesenchymal Stem Cell Osteogenic Differentiation by Glucocorticoid-induced Leucine Zipper (GILZ)*
It is shown that overexpression of GILZ in mouse MSCs, but not MC3T3-E1 osteoblasts, increases alkaline phosphatase activity and enhances mineralized bone nodule formation, whereas knockdown of Gilz reduces MSC osteogenic differentiation capacity.
Adipocyte differentiation of bone marrow-derived mesenchymal stem cells: Cross talk with the osteoblastogenic program
The molecular regulation of bone marrow adipogenesis is discussed with emphasis on signals that interact with osteoblastogenic pathways and the possible therapeutic implications of these interactions are highlighted.
Elucidating the role of YAP in directing mesenchymal stem cell fate
Observations indicate that depletion of YAP or TAZ leads to defective MSC, and YAP has a role in inhibiting adipogenesis in these cells.
A Reciprocal Role of the Smad4‐Taz Axis in Osteogenesis and Adipogenesis of Mesenchymal Stem Cells
Insight is provided into a novel function of Smad4 to regulate the balance of MSC lineage commitment through reciprocal targeting of the Taz protein in osteogenic and adipogenic differentiation pathways.
Umbilical cord mesenchymal stem cells: role of regulatory genes in their differentiation to osteoblasts.
The predominant expression by UC-MSCs of genes engaged in the osteogenic differentiation and their tendency to differentiate into osteoblasts, being similar in this respect to BM- MSCs, constitute a promising option for bone remodeling in regenerative medicine.
Identification of genes that regulate bone marrow stromal cell differentiation by RNA interference
Mesenchymal stem cells (MSCs) can be isolated from bone marrow and can differentiate in a variety of cell types, including osteoblasts, adipocytes, chondrocytes, myoblasts, hepatocytes, and neural


Transcriptional regulation of adipogenesis.
Although stem cell technology is developing rapidly, their recent introduction and the complexity inherent in these systems has prevented them from being extensively used in the adipogenesis field, studies have been performed using pluripotent stem cells that can be induced to yield adipose tissue in addition to several other lineages.
Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage [published erratum appears in J Cell Biol 1995 Feb;128(4):following 713]
Results indicate that BMP-2 specifically converts the differentiation pathway of C2C12 myoblasts into that of osteoblast lineage cells, but that the conversion is not heritable.
Multilineage potential of adult human mesenchymal stem cells.
Adult stem cells isolated from marrow aspirates of volunteer donors could be induced to differentiate exclusively into the adipocytic, chondrocytic, or osteocytic lineages.