TATA-binding protein and transcription factor IIB induce transcript slipping during early transcription by RNA polymerase II.

To better understand the mechanism of steps in early transcription by RNA polymerase II (pol II), we investigated the molecular determinants of transcript slipping within complexes assembled on promoters containing a pre-melted transcription bubble from -9 to +3. Transcript slippage occurs when an RNA transcript contains a repetitive sequence that allows… CONTINUE READING