TAT fusion proteins against ischemic stroke: current status and future perspectives.

  title={TAT fusion proteins against ischemic stroke: current status and future perspectives.},
  author={Ertugrul Kilic and Ulkan Kilic and Dirk Matthias Hermann},
  journal={Frontiers in bioscience : a journal and virtual library},
The delivery of proteins across the blood-brain barrier is severely limited by the proteins' size and biochemical properties. Thus, a large number of peptides have been characterized in recent years that efficaciously prevent neuronal death in vitro, but which may not be applied in vivo, since they are unable to cross cell membrane barriers. In the 1990ies, it had been shown that the HIV TAT protein is able to cross cell membranes even when coupled with larger peptides. Subsequent studies with… CONTINUE READING


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