TARP γ-7 selectively enhances synaptic expression of calcium-permeable AMPARs

@inproceedings{Studniarczyk2013TARPS,
  title={TARP γ-7 selectively enhances synaptic expression of calcium-permeable AMPARs},
  author={Dorota Studniarczyk and Ian D. Coombs and Stuart G Cull-Candy and Mark Farrant},
  booktitle={Nature Neuroscience},
  year={2013}
}
Regulation of calcium-permeable AMPA receptors (CP-AMPARs) is crucial in normal synaptic function and neurological disease states. Although transmembrane AMPAR regulatory proteins (TARPs) such as stargazin (γ-2) modulate the properties of calcium-impermeable AMPARs (CI-AMPARs) and promote their synaptic targeting, the TARP-specific rules governing CP-AMPAR synaptic trafficking remain unclear. We used RNA interference to manipulate AMPAR-subunit and TARP expression in γ-2–lacking stargazer… CONTINUE READING
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