TAP 29: an anti-human immunodeficiency virus protein from Trichosanthes kirilowii that is nontoxic to intact cells.

@article{LeeHuang1991TAP2A,
  title={TAP 29: an anti-human immunodeficiency virus protein from Trichosanthes kirilowii that is nontoxic to intact cells.},
  author={Sylvia Lee-Huang and Philip Lin Huang and Hsiang Fu Kung and Bao Qin Li and H. I. Huang and Hao Chen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1991},
  volume={88 15},
  pages={6570-4}
}
An anti-human immunodeficiency virus (anti-HIV) protein capable of inhibiting HIV-1 infection and replication has been isolated and purified to homogeneity from Trichosanthes kirilowii. This protein, TAP 29 (Trichosanthes anti-HIV protein, 29 kDa), is distinct from trichosanthin [also known as GLQ 223 (26 kDa)] in size, N-terminal amino acid sequence, and cytotoxicity. In addition to three conservative substitutions--namely, Arg-29 to Lys, Ile-37 to Val, and Pro-42 to Ser--a total difference of… CONTINUE READING