TAP, a novel T cell-activating protein involved in the stimulation of MHC-restricted T lymphocytes

@article{Rock1986TAPAN,
  title={TAP, a novel T cell-activating protein involved in the stimulation of MHC-restricted T lymphocytes},
  author={Kenneth L. Rock and Edward T. H. Yeh and Colette F. Gramm and Stephen Haber and Hans Reiser and Baruj Benacerraf},
  journal={The Journal of Experimental Medicine},
  year={1986},
  volume={163},
  pages={315 - 333}
}
Five mAbs have been generated and used to characterize TAP (T cell activating protein) a novel, functional murine T cell membrane antigen. The TAP molecule is a 12-kD protein that is synthesized by T cells. By antibody crossblocking, it appears to be closely associated with a 16-kD protein on the T cell membrane also identified with a novel mAb. These molecules are clearly distinct from the major well-characterized murine T cell antigens previously described. Antibody binding to TAP can result… CONTINUE READING

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