TAOK3, a novel genome-wide association study locus associated with morphine requirement and postoperative pain in a retrospective pediatric day surgery population.

@article{CookSather2014TAOK3AN,
  title={TAOK3, a novel genome-wide association study locus associated with morphine requirement and postoperative pain in a retrospective pediatric day surgery population.},
  author={Scott D. Cook-Sather and Jin Li and Theodora K Goebel and Emily M Sussman and Mohamed A. Rehman and Hakon Hakonarson},
  journal={Pain},
  year={2014},
  volume={155 9},
  pages={1773-83}
}
Candidate gene studies have revealed limited genetic bases for opioid analgesic response variability. Genome-wide association studies facilitate impartial queries of common genetic variants, allowing identification of novel genetic contributions to drug effect. Illumina (Illumina Inc, San Diego, CA, USA) single nucleotide polymorphism (SNP) arrays were used to investigate SNP associations with total morphine requirement as a quantitative trait locus and with postoperative pain in a… CONTINUE READING