TAM receptors regulate multiple features of microglial physiology

  title={TAM receptors regulate multiple features of microglial physiology},
  author={Lawrence Fourgeaud and Paqui G Trav{\'e}s and Yusuf Tufail and Humberto Leal-Bailey and Erin Lew and Patrick G. Burrola and Perri Callaway and Anna Zag{\'o}rska and Carla V Rothlin and Axel Nimmerjahn and Greg Lemke},
Microglia are damage sensors for the central nervous system (CNS), and the phagocytes responsible for routine non-inflammatory clearance of dead brain cells. Here we show that the TAM receptor tyrosine kinases Mer and Axl regulate these microglial functions. We find that adult mice deficient in microglial Mer and Axl exhibit a marked accumulation of apoptotic cells specifically in neurogenic regions of the CNS, and that microglial phagocytosis of the apoptotic cells generated during adult… CONTINUE READING
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