TAM receptor tyrosine kinases: expression, disease and oncogenesis in the central nervous system.

@article{Pierce2014TAMRT,
  title={TAM receptor tyrosine kinases: expression, disease and oncogenesis in the central nervous system.},
  author={Angela M. Pierce and Amy K. Keating},
  journal={Brain research},
  year={2014},
  volume={1542},
  pages={206-20}
}
Receptor tyrosine kinases (RTKs) are cell surface proteins that tightly regulate a variety of downstream intra-cellular processes; ligand-receptor interactions result in cascades of signaling events leading to growth, proliferation, differentiation and migration. There are 58 described RTKs, which are further categorized into 20 different RTK families. When dysregulated or overexpressed, these RTKs are implicated in disordered growth, development, and oncogenesis. The TAM family of RTKs… CONTINUE READING