TALL‐1 is a novel member of the TNF family that is down‐regulated by mitogens

@article{Shu1999TALL1IA,
  title={TALL‐1 is a novel member of the TNF family that is down‐regulated by mitogens},
  author={Hong-Bing Shu and Wenbin Hu and Holly Johnson},
  journal={Journal of Leukocyte Biology},
  year={1999},
  volume={65}
}
Members of the tumor necrosis factor (TNF) family play important roles in modulation of immune responses. We describe the identification and cloning of a novel TNF family member that has been designated as TALL‐1. TALL‐1 is a 285‐amino acid type II transmembrane protein. Its carboxy terminus shares ∼35% sequence identity with the recently identified APRIL and ∼20–25% with TNF, FasL, TRAIL, and lymphotoxin‐α, suggesting that TALL‐1 and APRIL belong to a subfamily of the TNF family of ligands… 
Identification of downstream genes up‐regulated by the tumor necrosis factor family member TALL‐1
TLDR
The identification of TALL‐1‐up‐regulated genes will help explain the mechanisms of Talls1‐triggered biological and pathological effects and to identify molecular targets for intervention of lupus‐like autoimmune diseases.
B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1.
  • H. Shu, H. Johnson
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2000
TLDR
The identification of BCMA as a NF-kappaB-activating receptor for TALL-1 suggests molecular targets for drug development against certain immunodeficient or autoimmune diseases.
Taci Is a Traf-Interacting Receptor for Tall-1, a Tumor Necrosis Factor Family Member Involved in B Cell Regulation
TLDR
The identification and characterization of the receptor for TALL-1 provides useful information for the development of a treatment for B cell-mediated autoimmune diseases such as systemic lupus erythematosus.
Macrophages express membrane bound form of APRIL that can generate immunomodulatory signals
TLDR
It is demonstrated that Macrophages express a membrane‐bound form of APRIL which, upon stimulation, modulates the activities of macrophages through stimulation or inhibition of processes associated with inflammation.
The uncertain glory of APRIL
TLDR
APRIL and B-lymphocyte stimulator form a new subfamily of TNF-like ligands that are expressed in haematopoietic cells and have recently been the subject of several reviews.
Ligand–receptor binding revealed by the TNF family member TALL-1
The tumour necrosis factor (TNF) ligand TALL-1 and its cognate receptors, BCMA, TACI and BAFF-R, were recently identified as members of the TNF superfamily, which are essential factors contributing
BAFF et al.: novel members of the TNF ligand and receptor families as therapeutic targets
TLDR
A new subfamily of TNF-related ligands/receptors, which also plays a role in immunity, has been discovered by sequence-homology database searches and offers the opportunity for developing novel treatment strategies for autoimmune diseases, immunodeficiencies, lymphoma and cancer.
The TNF family members BAFF and APRIL: the growing complexity.
Tumor Necrosis Factor (TNF) Receptor Superfamily Member TACI Is a High Affinity Receptor for TNF Family Members APRIL and BLyS*
TLDR
It is concluded that TACI is a receptor for BLyS and APRIL and the implications for B-cell biology are discussed.
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