TALEs from the genetic engineering of stem cells

The liver responds to insulin by blocking gluconeogenesis and stimulating lipogenesis. Insulininduced lipid synthesis requires induction of the transcription factor SREBP1c, which is mediated by the activation of mTORC1 (mammalian target of rapamycin complex 1), through the Aktdependent inhibition of the TSC1–TSC2 (tuberous sclerosis protein 1 and 2… (More)