TALEs from a Spring – Superelasticity of Tal Effector Protein Structures

  title={TALEs from a Spring – Superelasticity of Tal Effector Protein Structures},
  author={Holger Flechsig},
  journal={PLoS ONE},
Transcription activator-like effectors (TALEs) are DNA-related proteins that recognise and bind specific target sequences to manipulate gene expression. Recently determined crystal structures show that their common architecture reveals a superhelical overall structure that may undergo drastic conformational changes. To establish a link between structure and dynamics in TALE proteins we have employed coarse-grained elastic-network modelling of currently available structural data and implemented… 

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