TALENoffer: genome-wide TALEN off-target prediction

  title={TALENoffer: genome-wide TALEN off-target prediction},
  author={Jan Grau and Jens Boch and Stefan Posch},
  volume={29 22},
SUMMARY Transcription activator-like effector nucleases (TALENs) have become an accepted tool for targeted mutagenesis, but undesired off-targets remain an important issue. We present TALENoffer, a novel tool for the genome-wide prediction of TALEN off-targets. We show that TALENoffer successfully predicts known off-targets of engineered TALENs and yields a competitive runtime, scanning complete mammalian genomes within a few minutes. AVAILABILITY TALENoffer is available as a command line… CONTINUE READING
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2011)AnovelTALEnuclease scaffold enableshighgenomeediting

  • C Mussolino
  • TAL effectors. Science,
  • 2011
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