TALEN knockout of the PSIP1 gene in human cells: analyses of HIV-1 replication and allosteric integrase inhibitor mechanism.

@article{Fadel2014TALENKO,
  title={TALEN knockout of the PSIP1 gene in human cells: analyses of HIV-1 replication and allosteric integrase inhibitor mechanism.},
  author={Hind J. Fadel and James H. Morrison and Dyana T. Saenz and James R Fuchs and Mamuka Kvaratskhelia and Stephen C. Ekker and Eric M. Poeschla},
  journal={Journal of virology},
  year={2014},
  volume={88 17},
  pages={9704-17}
}
UNLABELLED HIV-1 utilizes the cellular protein LEDGF/p75 as a chromosome docking and integration cofactor. The LEDGF/p75 gene, PSIP1, is a potential therapeutic target because, like CCR5, depletion of LEDGF/p75 is tolerated well by human CD4+ T cells, and knockout mice have normal immune systems. RNA interference (RNAi) has been useful for studying LEDGF/p75, but the potent cofactor activity of small protein residua can be confounding. Here, in human cells with utility for HIV research (293T… CONTINUE READING
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