TALE nucleases: tailored genome engineering made easy.

  title={TALE nucleases: tailored genome engineering made easy.},
  author={Claudio Mussolino and Toni Cathomen},
  journal={Current opinion in biotechnology},
  volume={23 5},
Custom-made designer nucleases have evolved into an indispensable platform to precisely alter complex genomes for basic research, biotechnology, synthetic biology, or human gene therapy. In this review we describe how transcription activator-like effector nucleases (TALENs) have rapidly developed into a chief technology for targeted genome editing in different model organisms as well as human stem cells. We summarize the technological background and provide an overview of the current state-of… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 3 times over the past 90 days. VIEW TWEETS
80 Citations
74 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 80 extracted citations


Publications referenced by this paper.
Showing 1-10 of 74 references

A TALE nuclease architecture for efficient genome editing

  • JC Miller, S Tan, +7 authors SJ Hinkley
  • Nat Biotechnol
  • 2011
1 Excerpt

Similar Papers

Loading similar papers…