TALE nucleases: tailored genome engineering made easy.

@article{Mussolino2012TALENT,
  title={TALE nucleases: tailored genome engineering made easy.},
  author={Claudio Mussolino and Toni Cathomen},
  journal={Current opinion in biotechnology},
  year={2012},
  volume={23 5},
  pages={644-50}
}
Custom-made designer nucleases have evolved into an indispensable platform to precisely alter complex genomes for basic research, biotechnology, synthetic biology, or human gene therapy. In this review we describe how transcription activator-like effector nucleases (TALENs) have rapidly developed into a chief technology for targeted genome editing in different model organisms as well as human stem cells. We summarize the technological background and provide an overview of the current state-of… CONTINUE READING
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A TALE nuclease architecture for efficient genome editing

  • JC Miller, S Tan, +7 authors SJ Hinkley
  • Nat Biotechnol
  • 2011
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