TAK1 regulates autophagic cell death by suppressing the phosphorylation of p70 S6 kinase 1

Abstract

There is growing interest in identifying regulators of autophagy. The molecular mechanism underlying transforming growth factor-β activated kinase 1 (TAK1)-induced autophagy is poorly understood. We found that TAK1 inhibits p70 S6 kinase1 (S6K1) phosphorylation by interfering interaction of raptor with S6K1, thus inducing autophagy. The factors that… (More)
DOI: 10.1038/srep01561

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