TAK1 mitogen-activated protein kinase kinase kinase is activated by autophosphorylation within its activation loop.

@article{Kishimoto2000TAK1MP,
  title={TAK1 mitogen-activated protein kinase kinase kinase is activated by autophosphorylation within its activation loop.},
  author={Kyutaro Kishimoto and Kunihiro Matsumoto and Jun Ninomiya-Tsuji},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 10},
  pages={7359-64}
}
TAK1, a member of the mitogen-activated kinase kinase kinase family, is activated in vivo by various cytokines, including interleukin-1 (IL-1), or when ectopically expressed together with the TAK1-binding protein TAB1. However, this molecular mechanism of activation is not yet understood. We show here that endogenous TAK1 is constitutively associated with TAB1 and phosphorylated following IL-1 stimulation. Furthermore, TAK1 is constitutively phosphorylated when ectopically overexpressed with… CONTINUE READING
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