TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis.

@article{InokuchiShimizu2014TAK1mediatedAA,
  title={TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis.},
  author={Sayaka Inokuchi-Shimizu and Eek Joong Park and Yoon Seok Roh and Ling Yang and Bi Jun Zhang and Jingyi Song and Shuang Liang and Michael Pimienta and Koji Kamakura-shi Taniguchi and Xuefeng Wu and Kinji Asahina and William Lagakos and Mason R. Mackey and Shizuo Akira and Mark H. Ellisman and Dorothy D Sears and Jerrold M. Olefsky and M. Gilljam Karin and David Allen Brenner and Ekihiro Seki},
  journal={The Journal of clinical investigation},
  year={2014},
  volume={124 8},
  pages={
          3566-78
        }
}
The MAP kinase kinase kinase TGFβ-activated kinase 1 (TAK1) is activated by TLRs, IL-1, TNF, and TGFβ and in turn activates IKK-NF-κB and JNK, which regulate cell survival, growth, tumorigenesis, and metabolism. TAK1 signaling also upregulates AMPK activity and autophagy. Here, we investigated TAK1-dependent regulation of autophagy, lipid metabolism, and tumorigenesis in the liver. Fasted mice with hepatocyte-specific deletion of Tak1 exhibited severe hepatosteatosis with increased mTORC1… CONTINUE READING

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