TAK1 kinase determines TRAIL sensitivity by modulating reactive oxygen species and cIAP

@inproceedings{Morioka2009TAK1KD,
  title={TAK1 kinase determines TRAIL sensitivity by modulating reactive oxygen species and cIAP},
  author={Sho Morioka and Emily Omori and Taisuke Kajino and Rie Kajino-Sakamoto and Kunihiro Matsumoto and Jun Ninomiya-Tsuji},
  booktitle={Oncogene},
  year={2009}
}
TNF-related apoptosis-inducing ligand (TRAIL) is a potent inducer of cell death in several cancer cells, but many cells are resistant to TRAIL. The mechanism that determines sensitivity to TRAIL-killing is still elusive. Here we report that deletion of TAK1 kinase greatly increased activation of caspase-3 and cell death after TRAIL stimulation in keratinocytes, fibroblasts and cancer cells. Although TAK1 kinase is involved in NF-κB pathway, ablation of NF-κB did not alter sensitivity to TRAIL… CONTINUE READING

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