TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells.

@article{Sato2006TAK1II,
  title={TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells.},
  author={Shintaro Sato and Hideki Sanjo and Tohru Tsujimura and Jun Ninomiya-Tsuji and Masahiro Yamamoto and Taro Kawai and Osamu Takeuchi and Shizuo Akira},
  journal={International immunology},
  year={2006},
  volume={18 10},
  pages={1405-11}
}
Transforming growth factor (TGF)-beta-activating kinase 1 (TAK1) is critical for Toll-like receptor- and tumor necrosis factor-mediated cellular responses. In B cells, TAK1 is essential for the activation of mitogen-activated protein kinases (MAPKs), but not nuclear factor-kappaB (NF-kappaB), in antigen receptor signaling. In this study, we generate T cell-specific TAK1-deficient (Lck(Cre/(+))Tak1(flox/flox)) mice and show that TAK1 is indispensable for the maintenance of peripheral CD4 and CD8… CONTINUE READING