TAK1 is an essential regulator of BMP signalling in cartilage

@article{Shim2009TAK1IA,
  title={TAK1 is an essential regulator of BMP signalling in cartilage},
  author={Jae-Hyuck Shim and Matthew Blake Greenblatt and Min Xie and Michael D. Schneider and Weiguo Zou and Bo Zhai and Steven P Gygi and Laurie H Glimcher},
  journal={The EMBO Journal},
  year={2009},
  volume={28},
  pages={2028 - 2041}
}
  • Jae-Hyuck Shim, Matthew Blake Greenblatt, +5 authors Laurie H Glimcher
  • Published in The EMBO journal 2009
  • Medicine, Engineering, Biology
  • The EMBO Journal
  • TGFbeta activated kinase 1 (TAK1), a member of the MAPKKK family, controls diverse functions ranging from innate and adaptive immune system activation to vascular development and apoptosis. To analyse the in vivo function of TAK1 in cartilage, we generated mice with a conditional deletion of Tak1 driven by the collagen 2 promoter. Tak1(col2) mice displayed severe chondrodysplasia with runting, impaired formation of secondary centres of ossification, and joint abnormalities including elbow… CONTINUE READING

    Create an AI-powered research feed to stay up to date with new papers like this posted to ArXiv

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 62 CITATIONS, ESTIMATED 55% COVERAGE

    TAK 1 regulates skeletal muscle mass and mitochondrial function

    VIEW 17 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    TAK1 Regulates Cartilage and Joint Development via the MAPK and BMP Signaling Pathways

    VIEW 7 EXCERPTS
    CITES BACKGROUND, METHODS & RESULTS
    HIGHLY INFLUENCED

    BMP2 signaling in bone development and repair.

    • Vicki Rosen
    • Biology, Medicine
    • Cytokine & growth factor reviews
    • 2009
    VIEW 6 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    Focus on the p38 MAPK signaling pathway in bone development and maintenance.

    VIEW 6 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    FILTER CITATIONS BY YEAR

    2009
    2020

    CITATION STATISTICS

    • 6 Highly Influenced Citations

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 22 REFERENCES

    Indian Hedgehog produced by postnatal chondrocytes is essential for maintaining a growth plate and trabecular bone.

    VIEW 2 EXCERPTS

    Multiple functions of BMPs in chondrogenesis.

    VIEW 1 EXCERPT