TAK1 is a ubiquitin-dependent kinase of MKK and IKK

@article{wang2001TAK1IA,
  title={TAK1 is a ubiquitin-dependent kinase of MKK and IKK},
  author={chen wang and Li Deng and Mei Hong and Giridhar Rao Akkaraju and Jun-ichiro Inoue and Zhijian J. Chen},
  journal={Nature},
  year={2001},
  volume={412},
  pages={346-351}
}
TRAF6 is a signal transducer that activates IκB kinase (IKK) and Jun amino-terminal kinase (JNK) in response to pro-inflammatory mediators such as interleukin-1 (IL-1) and lipopolysaccharides (LPS). IKK activation by TRAF6 requires two intermediary factors, TRAF6-regulated IKK activator 1 (TRIKA1) and TRIKA2 (ref. 5). TRIKA1 is a dimeric ubiquitin-conjugating enzyme complex composed of Ubc13 and Uev1A (or the functionally equivalent Mms2). This Ubc complex, together with TRAF6, catalyses the… 

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TLDR
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TLDR
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TLDR
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