TAK1 inhibition attenuates both inflammation and fibrosis in experimental pneumoconiosis

  title={TAK1 inhibition attenuates both inflammation and fibrosis in experimental pneumoconiosis},
  author={Jie Li and Chao Liang and Zong-Kang Zhang and Xiao-hua Pan and Songlin Peng and Wing-Sze Lee and Aiping Lu and Zhixiu Lin and Ge Zhang and Wing Nang Leung and Bao-Ting Zhang},
  journal={Cell Discovery},
Pneumoconiosis, caused by inhalation of mineral dusts, is a major occupational disease worldwide. Currently, there are no effective drugs owing to a lack of potential therapeutic targets during either the inflammation or fibrosis molecular events in pneumoconiosis. Here, we performed microarrays to identify aberrantly expressed genes in the above molecular events in vitro and found a hub gene transforming growth factor-β-activated kinase 1 (TAK1), which was highly expressed and activated in… 

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  • F. Huaux
  • Medicine, Biology
    Current opinion in allergy and clinical immunology
  • 2007
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