TAK1 inhibition attenuates both inflammation and fibrosis in experimental pneumoconiosis

@article{Li2017TAK1IA,
  title={TAK1 inhibition attenuates both inflammation and fibrosis in experimental pneumoconiosis},
  author={Jie Li and Chao Liang and Zong-Kang Zhang and Xiao-hua Pan and Songlin Peng and Wing-Sze Lee and Aiping Lu and Zhixiu Lin and Ge Zhang and Wing Nang Leung and Bao-Ting Zhang},
  journal={Cell Discovery},
  year={2017},
  volume={3}
}
Pneumoconiosis, caused by inhalation of mineral dusts, is a major occupational disease worldwide. Currently, there are no effective drugs owing to a lack of potential therapeutic targets during either the inflammation or fibrosis molecular events in pneumoconiosis. Here, we performed microarrays to identify aberrantly expressed genes in the above molecular events in vitro and found a hub gene transforming growth factor-β-activated kinase 1 (TAK1), which was highly expressed and activated in… 
View on Nature
ncbi.nlm.nih.gov
34 Citations
Highly Influential Citations
1
Background Citations
9

34 Citations

Resveratrol attenuates the MSU crystal-induced inflammatory response through the inhibition of TAK1 activity.

The role of natural products in the prevention and treatment of pulmonary fibrosis: a review.

These natural products target oxidative stress, inflammatory injury, epithelial-mesenchymal transition (EMT), fibroblast activation, extracellular matrix accumulation and metabolic regulation, and the mechanisms involve the NF-κB, TGF-β1/Smad, PI3K/Akt, p38 MAPK, Nrf2-Nox4, and AMPK signaling pathways.

Pulmonary fibrosis: Therapeutic and mechanistic insights into the role of phytochemicals

Natural products, including plant extracts and active compound that directly target the processes involved in PF, could be suitable therapeutic options with less adverse effects.

Pathophysiological Roles of Stress-Activated Protein Kinases in Pulmonary Fibrosis

It is reported that the stepwise elevation of intrinsic p38 signaling in the lungs is correlated with a worsening severity of bleomycin-induced fibrosis, indicating an importance of this pathway in the progression of pulmonary fibrosis.

Lgals3bp suppresses colon inflammation and tumorigenesis through the downregulation of TAK1-NF-κB signaling

Lgals3bp plays a critical role in the suppression of colitis and colon tumorigenesis through the downregulation of the TAK1-NF-κB-cytokine axis, suggesting that LGALS3BP is a novel immunotherapeutic target for colon inflammation and tumorsigenesis.

Myeloid Differentiation Factor 2 in the Heart: Bench to bedside evidence for potential clinical benefits?

TAK1 blockade as a therapy for retinal neovascularization.

Intravitreal injection of 5Z-7-oxozeaenol significantly reduced hypoxia-induced inflammation and microglial activation, thus attenuating aberrant retinal angiogenesis in OIR rats and suggest that inhibition of TAK1 may have therapeutic potential for the treatment of retinal neovascular pathologies.

Resveratrol extracted from Chinese herbal medicines: A novel therapeutic strategy for lung diseases

TAK1: a potential therapeutic target for retinal neovascularization

The finding shows that TAK1 plays a key role in pathological angiogenesis in the retina, and selects inhibition of Tak1 by 5Z-7-oxozeaenol in vitro ameliorated pro-angiogenic activity, including endothelial cell proliferation, migration and tube formation.

Silencing TAK1 reduces MAPKs-MMP2/9 expression to reduce inflammation-driven neurohistological disruption post spinal cord injury

Data proved that in the early phase post SCI, TAK1 inhibition impedes microglia biological activities including activation, enzymatic synthesis, and migration via downregulation of MAPKs pathway, and the effects may be accurately characterized as potent anti-inflammation.

References

SHOWING 1-10 OF 72 REFERENCES

Silica-induced NLRP3 inflammasome activation in vitro and in rat lungs

DQ12 quartz exposure induced acute and chronic functional activation of the inflammasome in the heterogeneous cell populations of the lung in associated with its crystalline surface reactivity, indicating that the development of silicosis and inflammaome activation is determined by crystalline silica surface reactsivity.

New developments in the understanding of immunology in silicosis

  • F. Huaux
  • Medicine, Biology
    Current opinion in allergy and clinical immunology
  • 2007
New pathogenic routes involving innate receptors and antiinflammation as well as new antifibrotic immune mediators have been recently described in experimental silicosis, highlighting new potential therapeutic targets and strategies.

TAK1 inhibition prevents the development of autoimmune diabetes in NOD mice

The results indicate that TAK1 inhibition with OZ was associated with a lower frequency of autoimmune diabetes in NOD mice, and the net effect of Tak1 inhibition in Nod mice appears to be protective rather than disease-enhancing.

TAK1 Is a Central Mediator of NOD2 Signaling in Epidermal Cells*

It is shown that transforming growth factor β-activated kinase 1 (TAK1) is an essential intermediate of NOD2 signaling and its ablation may impair the skin barrier function leading to inflammation.

Silicosis: a review.

Amelioration of emphysema in mice through lentiviral transduction of long-lived pulmonary alveolar macrophages.

An intratracheally instilled lentiviral system able to deliver genes selectively to as many as 70% of alveolar macrophages (AMs) in the mouse lung is described and it is suggested that these differentiated cells may be a possible target cell population for in vivo gene therapy applications, including the sustained correction of hAAT deficiency.

Silicosis and coal workers' pneumoconiosis.

Exposure to coal mine dust and/or crystalline silica results in pneumoconiosis with initiation and progression of pulmonary fibrosis. This review presents characteristics of simple and complicated…

The impact of TGF-β on lung fibrosis: from targeting to biomarkers.

This review will focus on discussing novel data and highlighting growing interest in deepening the understanding of the profibrotic role of TGF-β and its direct or indirect targeting for disease modulation.

Sirt1 Activation Ameliorates Renal Fibrosis by Inhibiting the TGF‐β/Smad3 Pathway

The results identify Sirt1 as an important protective factor for renal fibrosis in a CKD rodent model, and the protective function of Sirt 1 is attributable to its action on TGF‐β/Smad3 signaling.

Mechanistically Identified Suitable Biomarkers of Exposure, Effect, and Susceptibility for Silicosis and Coal-Worker'S Pneumoconiosis: A Comprehensive Review

A number of “ideal” biological markers of effect were identified, namely, Clara cell protein-16 (CC16) (serum), tumor necrosis factor-α (TNF-α) (Monocyte release), interleukin-8 (IL-8) (monocyte release) and reactive oxygen species (ROS) measurement by chemiluminescence (neutrophil release).
...