TAK1 inhibition attenuates both inflammation and fibrosis in experimental pneumoconiosis

@article{Li2017TAK1IA,
  title={TAK1 inhibition attenuates both inflammation and fibrosis in experimental pneumoconiosis},
  author={Jie Li and Chao Liang and Zongkang Zhang and Xiao-hua Pan and Songlin Peng and W. W. Lee and Aiping Lu and Zhixiu Lin and Ge Zhang and Wing Nang Leung and Baoting Zhang},
  journal={Cell Discovery},
  year={2017},
  volume={3}
}
Pneumoconiosis, caused by inhalation of mineral dusts, is a major occupational disease worldwide. Currently, there are no effective drugs owing to a lack of potential therapeutic targets during either the inflammation or fibrosis molecular events in pneumoconiosis. Here, we performed microarrays to identify aberrantly expressed genes in the above molecular events in vitro and found a hub gene transforming growth factor-β-activated kinase 1 (TAK1), which was highly expressed and activated in… 
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Resveratrol attenuates the MSU crystal-induced inflammatory response through the inhibition of TAK1 activity.
TLDR
Resveratrol may have a potential therapeutic effect on gouty arthritis by inhibiting TAK1 activity, which is closely associated with the NF-κB and MAPK signaling pathways.
The role of natural products in the prevention and treatment of pulmonary fibrosis: a review.
TLDR
These natural products target oxidative stress, inflammatory injury, epithelial-mesenchymal transition (EMT), fibroblast activation, extracellular matrix accumulation and metabolic regulation, and the mechanisms involve the NF-κB, TGF-β1/Smad, PI3K/Akt, p38 MAPK, Nrf2-Nox4, and AMPK signaling pathways.
Pulmonary fibrosis: Therapeutic and mechanistic insights into the role of phytochemicals
TLDR
Natural products, including plant extracts and active compound that directly target the processes involved in PF, could be suitable therapeutic options with less adverse effects.
Pathophysiological Roles of Stress-Activated Protein Kinases in Pulmonary Fibrosis
TLDR
It is reported that the stepwise elevation of intrinsic p38 signaling in the lungs is correlated with a worsening severity of bleomycin-induced fibrosis, indicating an importance of this pathway in the progression of pulmonary fibrosis.
TAK1 signaling is a potential therapeutic target for pathological angiogenesis.
TLDR
The rationales of therapeutic strategies based on TAK1 inhibition for the treatment of pathological angiogenesis are highlighted and the crosstalk between Tak1 and signaling pathways involved in pathological ang iogenesis is discussed.
Lgals3bp suppresses colon inflammation and tumorigenesis through the downregulation of TAK1-NF-κB signaling
TLDR
Lgals3bp plays a critical role in the suppression of colitis and colon tumorigenesis through the downregulation of the TAK1-NF-κB-cytokine axis, suggesting that LGALS3BP is a novel immunotherapeutic target for colon inflammation and tumorsigenesis.
CPEB1 or CPEB4 knockdown suppresses the TAK1 and Smad signalings in THP-1 macrophage-like cells and dermal fibroblasts.
TLDR
The findings indicate that CPEB1 and C PEB4 are involved in the regulation of the TAK1 and Smad signalings in human macrophages and dermal fibroblasts and may play a role in cutaneous scarring responses.
Myeloid Differentiation Factor 2 in the Heart: Bench to bedside evidence for potential clinical benefits?
TLDR
The reports from in vitro, in vivo, and clinical studies regarding the role of MD2 and the effects ofMD2 inhibitors on cardiac inflammation, dysfunction, fibrosis, and remodeling are summarized to encourage future clinical use as a novel anti-inflammatory agent.
TAK1 blockade as a therapy for retinal neovascularization
TLDR
Results reveal that inhibition of TAK1 signaling may have therapeutic value for the treatment of pathological angiogenesis in the retina.
Resveratrol extracted from Chinese herbal medicines: A novel therapeutic strategy for lung diseases
TLDR
In this review, the recent progress in the studies of lung-protective effects and underlying mechanisms of resveratrol are highlighted and traditional Chinese prescriptions containing resver atrol as promising therapeutic options were summarized for the treatment of lung and respiratory diseases.
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