TAGing APP constrains neurogenesis

  title={TAGing APP constrains neurogenesis},
  author={Mark P. Mattson and Henriette van Praag},
  journal={Nature Cell Biology},
The cell adhesion molecule TAG1 has been identified as the ligand that induces β-amyloid precursor protein (APP) processing and signalling, resulting in the inhibition of neurogenesis. These findings demonstrate a critical role of TAG1–APP signalling in brain development and suggest the potential involvement of TAG1 in adult neuroplasticity and pathogenesis of Alzheimer's disease. 


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