TAGLN2 regulates T cell activation by stabilizing the actin cytoskeleton at the immunological synapse


The formation of an immunological synapse (IS) requires tight regulation of actin dynamics by many actin polymerizing/depolymerizing proteins. However, the significance of actin stabilization at the IS remains largely unknown. In this paper, we identify a novel function of TAGLN2--an actin-binding protein predominantly expressed in T cells--in stabilizing… (More)
DOI: 10.1083/jcb.201407130