TAGE (toxic AGEs) theory in diabetic complications.

  title={TAGE (toxic AGEs) theory in diabetic complications.},
  author={Takashi Sato and Mina Iwaki and Noriko Shimogaito and Xuegang Wu and Sho-ichi Yamagishi and Masayoshi Takeuchi},
  journal={Current molecular medicine},
  volume={6 3},
Diabetic complication is a leading cause of acquired blindness, end-stage renal failure, a variety of neuropathies and accelerated atherosclerosis. Chronic hyperglycemia is initially involved in the pathogenesis of diabetic micro- and macro-vascular complications via various metabolic derangements. High glucose increased production of various types of advanced glycation end-products (AGEs). Recently, we found that glyceraldehyde-derived AGEs (AGE-2) play an important role in the pathogenesis of… CONTINUE READING