TAF-like function of SV40 large T antigen.

  title={TAF-like function of SV40 large T antigen.},
  author={Blossom Damania and James C. Alwine},
  journal={Genes & development},
  volume={10 11},
The simian virus 40 (SV40) early gene product large T antigen promiscuously activates simple promoters containing a TATA box or initiator element and at least one upstream transcription factor-binding site. Previous studies have suggested that promoter activation requires that large T antigen interacts with both the basal transcription complex and the upstream-bound factor. This mechanism of activation is similar to that proposed for TBP-associated factors (TAFs). We report genetic and… CONTINUE READING


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