TACE-mediated ectodomain shedding of the type I TGF-β receptor downregulates TGF-β signaling

@inproceedings{Liu2009TACEmediatedES,
  title={TACE-mediated ectodomain shedding of the type I TGF-β receptor downregulates TGF-β signaling},
  author={Cheng Qiang Liu and Pinglong Xu and Samy Lamouille and J Xu and Rik Derynck},
  year={2009}
}
Regulating TGF-β receptor presentation provides an avenue to alter a cell’s responsiveness to TGFβ. We report that activation of the Erk MAP kinase pathway decreases the TGF-β-induced Smad3 activation, due to decreased cell surface levels of the type I receptor TβRI, but not the type II receptor. Inhibition of TACE activity or expression enhanced the cell surface TβRI levels and TGF-β-induced Smad3 and Akt activation. Accordingly, silencing TACE expression in cancer cells enhanced the TβRI… CONTINUE READING

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