TAB3 O-GlcNAcylation promotes metastasis of triple negative breast cancer

@inproceedings{Tao2016TAB3OP,
  title={TAB3 O-GlcNAcylation promotes metastasis of triple negative breast cancer},
  author={Tao Tao and Zhixian He and Zhi-Ming Shao and Haojie Lu},
  booktitle={Oncotarget},
  year={2016}
}
O-GlcNAcylation is a post-translational modification that regulates a broad range of nuclear and cytoplasmic proteins and is emerging as a key regulator of various biological processes. Although previous studies have shown that increased levels of global O-GlcNAcylation and O-GlcNActransferase are linked to the incidence of metastasis in triple negative breast cancer (TNBC) patients, the molecular basis behind this is not fully understood. In this study, we have determined that the TAK1 binding… CONTINUE READING

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