TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction.

  title={TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction.},
  author={Hirotaka Shibuya and Kentaro Yamaguchi and Kyoko Shirakabe and Akane Tonegawa and Yukiko Gotoh and Naoto Ueno and Kenji Irie and Eisuke Nishida and Kunihiro Matsumoto},
  volume={272 5265},
Transforming growth factor-beta (TGF-beta) regulates many aspects of cellular function. A member of the mitogen-activated protein kinase kinase kinase (MAPKKK) family, TAK1, was previously identified as a mediator in the signaling pathway of TGF-beta superfamily members. The yeast two-hybrid system has now revealed two human proteins, termed TAB1 and TAB2 (for TAK1 binding protein), that interact with TAK1. TAB1 and TAK1 were co-immunoprecipitated from mammalian cells. Overproduction of TAB1… CONTINUE READING
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