TA repeat polymorphism of the 5alpha-reductase gene and breast cancer.

@article{Bharaj2000TARP,
  title={TA repeat polymorphism of the 5alpha-reductase gene and breast cancer.},
  author={Bhupinder B Bharaj and Andreas Scorilas and Maurizia Giai and Eleftherios P Diamandis},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  year={2000},
  volume={9 4},
  pages={387-93}
}
There is increasing evidence that androgens play a significant role in the development and progression of breast cancer. 5alpha-Reductase (SRD5A2) is an enzyme that is expressed in androgen-dependent tissues, and it catalyzes the reduction of testosterone to its more bioactive form, dihydrotestosterone, which then transactivates a number of genes. One of these genes encodes for prostate-specific antigen (PSA), a favorable prognostic factor in breast cancer. The 3' untranslated region of the… CONTINUE READING