T594M mutation of the epithelial sodium channel beta-subunit gene in pre-eclampsia and eclampsia in Black South African women.

@article{Pegoraro2004T594MMO,
  title={T594M mutation of the epithelial sodium channel beta-subunit gene in pre-eclampsia and eclampsia in Black South African women.},
  author={Rosemary J. Pegoraro and Candice Roberts and Lee Rom and Jack Moodley},
  journal={BJOG : an international journal of obstetrics and gynaecology},
  year={2004},
  volume={111 9},
  pages={1012-3}
}
The possible role of the beta-subunit of the epithelial sodium channel T594M polymorphism in hypertensive disorders of pregnancy has not been examined. This study compared Black South African women with pre-eclampsia (n= 204), early onset pre-eclampsia (n= 67), eclampsia (n= 120) and gestational hypertension (n= 78) with 338 women from the same ethnic group who had full-term normotensive pregnancies, for the presence of the T594M polymorphism. The variant allele was detected in 1.7% to 3.8% of… CONTINUE READING