T47D breast cancer cell growth is inhibited by expression of VACM-1, a cul-5 gene.

@article{BurnatowskaHledin2004T47DBC,
  title={T47D breast cancer cell growth is inhibited by expression of VACM-1, a cul-5 gene.},
  author={Maria A Burnatowska-Hledin and Jennifer B Kossoris and Christa J Van Dort and Rebecca L. Shearer and Ping Zhao and Douglas A. Murrey and Jessica L Abbott and Charlene E. Kan and Christopher Barney},
  journal={Biochemical and biophysical research communications},
  year={2004},
  volume={319 3},
  pages={817-25}
}
Vasopressin-activated calcium-mobilizing (VACM-1), a cul-5 gene, is localized on chromosome 11q22-23 close to the gene for Ataxia Telangiectasia in a region associated with a loss of heterozygosity in breast cancer tumor samples. To examine the biological role of VACM-1, we studied the effect of VACM-1 expression on cellular growth and gene expression in T47D breast cancer cells. Immunocytochemistry studies demonstrated that VACM-1 was expressed in 0.6-6% of the T47D cells and localized to the… CONTINUE READING

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