T4 DNA topoisomerase: a new ATP-dependent enzyme essential for initiation of T4 bacteriophage DNA replication
@article{Liu1979T4DT, title={T4 DNA topoisomerase: a new ATP-dependent enzyme essential for initiation of T4 bacteriophage DNA replication}, author={Leroy F. Liu and Chung‐Cheng Liu and Bruce Alberts}, journal={Nature}, year={1979}, volume={281}, pages={456-461} }
A novel ATP-dependent DNA topoisomerase which makes reversible double-strand breaks in the DNA double helix has been purified to near homogeneity from T4 bacteriophage-infected Escherichia coli cells. Genetic data suggest that this activity is essential for initiating T4 DNA replication forks in vivo.
203 Citations
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