T3 stimulates resting metabolism and UCP-2 and UCP-3 mRNA but not nonphosphorylating mitochondrial respiration in mice.

@article{Jekabsons1999T3SR,
  title={T3 stimulates resting metabolism and UCP-2 and UCP-3 mRNA but not nonphosphorylating mitochondrial respiration in mice.},
  author={Mika B. Jekabsons and Francine M. Gregoire and Nancy A. Schonfeld-Warden and Craig H Warden and Barbara A Horwitz},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={1999},
  volume={277 2},
  pages={E380-E389}
}
The molecular basis for variations in resting metabolic rate (RMR) within a species is unknown. One possibility is that variations in RMR occur because of variations in uncoupling protein 2 (UCP-2) and uncoupling protein 3 (UCP-3) expression, resulting in mitochondrial proton leak differences. We tested the hypothesis that UCP-2 and -3 mRNAs positively correlate with RMR and proton leak. We treated thyroidectomized and sham-operated mice with triiodothyronine (T3) or vehicle and measured RMR… CONTINUE READING
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