T2R38 genotype is correlated with sinonasal quality of life in homozygous ΔF508 cystic fibrosis patients.

@article{Adappa2016T2R38GI,
  title={T2R38 genotype is correlated with sinonasal quality of life in homozygous ΔF508 cystic fibrosis patients.},
  author={Nithin D. Adappa and Alan D Workman and Denis Hadjiliadis and Daniel J Dorgan and Danielle Frame and Steven G. Brooks and Laurel Doghramji and James N. Palmer and Corrine J. Mansfield and Danielle R Reed and Noam A Cohen},
  journal={International forum of allergy & rhinology},
  year={2016},
  volume={6 4},
  pages={
          356-61
        }
}
BACKGROUND Chronic rhinosinusitis (CRS) is very prevalent in the cystic fibrosis (CF) patient population, and leads to high morbidity and markedly decreased quality of life (QOL). Identification of genetic markers that contribute to CRS symptoms in these patients can allow for risk stratification and tailoring of medical and surgical treatments. T2R38 is a bitter taste receptor expressed in the sinonasal tract, and nonfunctional alleles of this receptor have been implicated in treatment… CONTINUE READING

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