T2-TrpRS inhibits preretinal neovascularization and enhances physiological vascular regrowth in OIR as assessed by a new method of quantification.

@article{Banin2006T2TrpRSIP,
  title={T2-TrpRS inhibits preretinal neovascularization and enhances physiological vascular regrowth in OIR as assessed by a new method of quantification.},
  author={Eyal Banin and Michael Ian Dorrell and Edith Aguilar and Matthew R. Ritter and Christopher M. Aderman and Alexandra C. H. Smith and Jeffrey Friedlander and Martin Friedlander},
  journal={Investigative ophthalmology & visual science},
  year={2006},
  volume={47 5},
  pages={2125-34}
}
PURPOSE A carboxyl-terminal fragment of tryptophan tRNA synthetase (T2-TrpRS) has demonstrated potent angiostatic activity during retinal developmental neovascularization in vivo. The effects of T2-TrpRS on pathologic neovascularization were tested and compared with a potent VEGF antagonist using the mouse model of oxygen-induced retinopathy (OIR). METHODS C57BL/6J mice were transiently exposed to hyperoxic conditions (75% O2) between postnatal day 7 (P7) and P12 and then returned to room air… CONTINUE READING