T-type calcium channels: From molecule to therapeutic opportunities.
@article{Weiss2019TtypeCC, title={T-type calcium channels: From molecule to therapeutic opportunities.}, author={Norbert Weiss and Gerald W. Zamponi}, journal={The international journal of biochemistry \& cell biology}, year={2019}, volume={108}, pages={ 34-39 } }
58 Citations
T-Type Calcium Channels: A Mixed Blessing
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The relevance of T-type calcium channels in cancer and in chemotherapy side effects is put into context, considering also the cardiotoxicity induced by new classes of antineoplastic molecules.
T-Type Channel Druggability at a Crossroads.
- BiologyACS chemical neuroscience
- 2019
The potential of T-type channels as druggable targets is discussed and the strategies available for developing therapeutically efficient and specific modulators of this channel are reevaluate.
Selective inhibition of neuronal Cav3.3 T-type calcium channels by TAT-based channel peptide
- BiologyMolecular Brain
- 2020
The ability of a TAT-based cell penetrating peptide containing this carboxy proximal region (TAT-C3P) to modulate the activity of Cav3 channels is explored and it is shown that chronic application of Tat-C4P on tsA-201 cells expressing Cav3 channel selectively inhibits Cav3.3 channels.
Calcium Channels in the Heart: Disease States and Drugs
- Biology, MedicineCells
- 2022
The type of cardiac calcium channels, their function, and disorders caused by their mutations and dysfunctions are summarized and the types of calcium channel blockers and their use in a variety of cardiac disorders are focused on.
Small Molecules as Modulators of Voltage-Gated Calcium Channels in Neurological Disorders: State of the Art and Perspectives
- Biology, MedicineMolecules
- 2022
An overview of the role of calcium channels in neurological disorders is provided and possible strategies to generate novel therapeutics are discussed to treat such prevailing conditions of the central nervous system.
The life cycle of voltage-gated Ca2+ channels in neurons: an update on the trafficking of neuronal calcium channels
- BiologyNeuronal signaling
- 2021
The current evidence concerning the regulatory mechanisms which underlie precise control of neuronal CaV channel trafficking are addressed and their potential as therapeutic targets are discussed.
Interactions with PDZ proteins diversify voltage‐gated calcium channel signaling
- BiologyJournal of neuroscience research
- 2020
The role of PDZ proteins in controlling channel activity, regulating channel cell surface density, and influencing channel‐mediated downstream signaling events is discussed and the link between this regulatory effect and human disease is evaluated.
A potential role for T-type calcium channels in homocysteinemia-induced peripheral neuropathy.
- BiologyPain
- 2019
An unrecognized signaling pathway that modulates the expression of T-type calcium channels is revealed, and may potentially contribute to the development of peripheral neuropathy associated with homocysteinemia.
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Selective inhibition of neuronal Cav3.3 T-type calcium channels by TAT-based channel peptide
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The ability of a TAT-based cell penetrating peptide containing this carboxy proximal region (TAT-C3P) to modulate the activity of Cav3 channels is explored and it is shown that chronic application of Tat-C4P on tsA-201 cells expressing Cav3 channel selectively inhibits Cav3.3 channels.
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