T-type calcium channel regulation by specific G-protein βγ subunits

@article{Wolfe2003TtypeCC,
  title={T-type calcium channel regulation by specific G-protein $\beta$$\gamma$ subunits},
  author={Joshua T. Wolfe and Hongge Wang and Jason Howard and James C. Garrison and Paula Q. Barrett},
  journal={Nature},
  year={2003},
  volume={424},
  pages={209-213}
}
Low-voltage-activated (LVA) T-type calcium channels have a wide tissue distribution and have well-documented roles in the control of action potential burst generation and hormone secretion. In neurons of the central nervous system and secretory cells of the adrenal and pituitary, LVA channels are inhibited by activation of G-protein-coupled receptors that generate membrane-delimited signals, yet these signals have not been identified. Here we show that the inhibition of α1H (Cav3.2), but not… 

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