T-type calcium channel blockers - new and notable.

@article{Lacinov2011TtypeCC,
  title={T-type calcium channel blockers - new and notable.},
  author={Ľubica Lacinov{\'a}},
  journal={General physiology and biophysics},
  year={2011},
  volume={30 4},
  pages={403-9}
}
Since cloning of the T-type or Ca(V)3.n calcium channel family in 1998-1999 much progress was made in investigation of their regulation. Most effective metal Ca(V)3 channel blockers are trivalent cations from lanthanide group together with transition metals La(3+) and Y(3+). Divalent cations Zn(2+), Cu(2+) and Ni(2+) inhibit Ca(V)3.2 channels more efficiently than Ca(V)3.1 and Ca(V)3.3 channels via second high-affinity binding site including histidine H191 specific for the Ca(V)3.2 channel… CONTINUE READING

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