T-type and N-type calcium channels of Xenopus oocytes: evidence for specific interactions with beta subunits.

@article{Lacerda1994TtypeAN,
  title={T-type and N-type calcium channels of Xenopus oocytes: evidence for specific interactions with beta subunits.},
  author={Ant{\'o}nio Lacerda and Edward Perez-Reyes and Xiquan Wei and Antonio Castellano and Arthur M. Brown},
  journal={Biophysical journal},
  year={1994},
  volume={66 6},
  pages={1833-43}
}
We used amplifying effects of calcium channel beta subunits to identify endogenous calcium channels in Xenopus oocytes. Expression of rat brain beta 4 increased macroscopic endogenous current magnitude with a small effect on kinetics. In contrast, expression of rat brain/cardiac beta 2 produced a much larger increase in current magnitude and dramatically slowed current decay. Low concentrations of omega-conotoxin GVIA irreversibly blocked currents in both uninjected and beta 2-injected oocytes… CONTINUE READING

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