T regulatory cells control T-cell proliferation partly by the release of soluble CD25 in patients with B-cell malignancies.

@article{Lindqvist2010TRC,
  title={T regulatory cells control T-cell proliferation partly by the release of soluble CD25 in patients with B-cell malignancies.},
  author={Camilla A Lindqvist and Lisa H Christiansson and Bengt Simonsson and Gunilla Enblad and Ulla Olsson-Str{\"o}mberg and Angelica Loskog},
  journal={Immunology},
  year={2010},
  volume={131 3},
  pages={371-6}
}
Interleukin-2 (IL-2) is one of the most studied cytokines driving T-cell proliferation, activation and survival. It binds to the IL-2 receptor consisting of three chains, the α (CD25), β and common γ (γc). The binding of the CD25 chain to IL-2 is necessary to expose high-affinity binding sites for the β and γc chains, which, in turn, are responsible for downstream signalling. A high level of soluble CD25 (sCD25) has been associated with a poor prognosis in patients with non-Hodgkin's lymphoma… CONTINUE READING

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