T regulatory cells contribute to the attenuated primary CD8+ and CD4+ T cell responses to herpes simplex virus type 2 in neonatal mice.

@article{Fernandez2008TRC,
  title={T regulatory cells contribute to the attenuated primary CD8+ and CD4+ T cell responses to herpes simplex virus type 2 in neonatal mice.},
  author={Marian A. Fernandez and Franz K. Puttur and Yuan Wang and Wade Howden and Stephen I. Alexander and Cheryl Anne Jones},
  journal={Journal of immunology},
  year={2008},
  volume={180 3},
  pages={1556-64}
}
The first weeks of life are characterized by immune tolerance and increased susceptibility to intracellular pathogens. The neonatal adaptive response to HSV is attenuated compared with adult control models in humans and mice. T Regulatory cells (Tregs) control autoimmunity and excessive immune responses to infection. We therefore compared Treg responses in the draining lymph nodes (LN) of HSV-infected neonatal and adult C57BL/6 mice with the effect of Treg depletion/inactivation by anti-CD25… CONTINUE READING