T lymphocytes redirected against the kappa light chain of human immunoglobulin efficiently kill mature B lymphocyte-derived malignant cells.

@article{Vera2006TLR,
  title={T lymphocytes redirected against the kappa light chain of human immunoglobulin efficiently kill mature B lymphocyte-derived malignant cells.},
  author={Juan Vera and Barbara Savoldo and St{\'e}phane Vigouroux and Ettore Biagi and Martin A Pule and Claudia Rossig and Jessie Yu-Chieh Wu and Helen E Heslop and Cliona M Rooney and Malcolm K. Brenner and Gianpietro Dotti},
  journal={Blood},
  year={2006},
  volume={108 12},
  pages={3890-7}
}
There has been interest in generating T cells expressing chimeric artificial receptors (CARs) targeting CD19/CD20 antigens to treat B-cell lymphomas. If successful, however, this approach would likely impair humoral immunity because T cells may persist long-term. Most low-grade lymphoma and chronic lymphocytic leukemia (B-CLL) cells express monoclonal immunoglobulins carrying either kappa or lambda light chains. We, therefore, explored whether T lymphocytes could be genetically modified to… CONTINUE READING
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