T lymphocytes promote the development of bone marrow-derived APC in the central nervous system.


Certain cells within the CNS, microglial cells and perivascular macrophages, develop from hemopoietic myelomonocytic lineage progenitors in the bone marrow (BM). Such BM-derived cells function as CNS APC during the development of T cell-mediated paralytic inflammation in diseases such as experimental autoimmune encephalomyelitis and multiple sclerosis. We used a novel, interspecies, rat-into-mouse T cell and/or BM cell-transfer method to examine the development and function of BM-derived APC in the CNS. Activated rat T cells, specific for either myelin or nonmyelin Ag, entered the SCID mouse CNS within 3-5 days of cell transfer and caused an accelerated recruitment of BM-derived APC into the CNS. Rat APC in the mouse CNS developed from transferred rat BM within an 8-day period and were entirely sufficient for induction of CNS inflammation and paralysis mediated by myelin-specific rat T cells. The results demonstrate that T cells modulate the development of BM-derived CNS APC in an Ag-independent fashion. This previously unrecognized regulatory pathway, governing the presence of functional APC in the CNS, may be relevant to pathogenesis in experimental autoimmune encephalomyelitis, multiple sclerosis, and/or other CNS diseases involving myelomonocytic lineage cells.

5 Figures and Tables


Citations per Year

184 Citations

Semantic Scholar estimates that this publication has 184 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Subramanian2001TLP, title={T lymphocytes promote the development of bone marrow-derived APC in the central nervous system.}, author={Sandhya Subramanian and Dennis N. Bourdette and Chelsea Corless and Arthur A . Vandenbark and Halina A. Offner and Richard E. Jones}, journal={Journal of immunology}, year={2001}, volume={166 1}, pages={370-6} }