T lymphocytes interact with hepatocytes through fenestrations in murine liver sinusoidal endothelial cells.

@article{Warren2006TLI,
  title={T lymphocytes interact with hepatocytes through fenestrations in murine liver sinusoidal endothelial cells.},
  author={Alessandra Warren and David G. Le Couteur and Robin Fraser and David Geoffrey Bowen and Geoffrey W Mccaughan and Patrick Bertolino},
  journal={Hepatology},
  year={2006},
  volume={44 5},
  pages={1182-90}
}
The liver has an established ability to induce tolerance. Recent evidence indicates that this unique property might be related to its distinctive architecture allowing T cells to be activated in situ independently of lymphoid tissues. Unlike lymph node-activated T cells, liver-activated T cells are short-lived, a mechanism that might contribute to the "liver tolerance effect." Although the potential role of hepatocytes as tolerogenic antigen-presenting cells has been demonstrated, the question… CONTINUE READING

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