T lymphocytes in collagen II-induced arthritis in mice. Characterization of arthritogenic collagen II-specific T-cell lines and clones.

@article{Holmdahl1985TLI,
  title={T lymphocytes in collagen II-induced arthritis in mice. Characterization of arthritogenic collagen II-specific T-cell lines and clones.},
  author={Rikard Holmdahl and Lars Klareskog and Kristofer Rubin and E. -L. Larsson and Hans Wigzell},
  journal={Scandinavian journal of immunology},
  year={1985},
  volume={22 3},
  pages={295-306}
}
Collagen type II-specific long-term cultured T helper cells, derived from the DBA/1 mouse, have been established and characterized. Clones from these T-cell lines could be shown to recognize either species-specific or species-nonspecific determinants on the collagen type II molecule, including determinants on autologous mouse collagen. Induction of arthritis via transfer to both irradiated and normal syngeneic recipient mice was obtained with both collagen type II-specific T-cell lines and an… CONTINUE READING