T-lymphocytes: a target for stimulatory and inhibitory effects of zinc ions.

  title={T-lymphocytes: a target for stimulatory and inhibitory effects of zinc ions.},
  author={Andrea H{\"o}nscheid and Lothar Rink and Hajo Haase},
  journal={Endocrine, metabolic & immune disorders drug targets},
  volume={9 2},
The trace element zinc is a crucial cofactor for many proteins involved in cellular processes like differentiation, proliferation and apoptosis. Zinc homeostasis is tightly regulated and disturbance of this homeostasis due to genetic defects, zinc deficiency, or supplementation influences the development and the progression of various infectious and autoimmune diseases. The immune system is strongly impaired during zinc deficiency, predominantly the cell-mediated response by T-lymphocytes… CONTINUE READING
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