T-lymphocyte response to cytochrome c. I. Demonstration of a T-cell heteroclitic proliferative response and identification of a topographic antigenic determinant on pigeon cytochrome c whose immune recognition requires two complementing major histocompatibility complex-linked immune response genes

@article{Solinger1979TlymphocyteRT,
  title={T-lymphocyte response to cytochrome c. I. Demonstration of a T-cell heteroclitic proliferative response and identification of a topographic antigenic determinant on pigeon cytochrome c whose immune recognition requires two complementing major histocompatibility complex-linked immune response genes},
  author={Alan M. Solinger and Michiel E. Ultee and Emanuel Margoliash and R. H. Schwartz},
  journal={The Journal of Experimental Medicine},
  year={1979},
  volume={150},
  pages={830 - 848}
}
The T-lymphocyte proliferative response to pigeon cytochrome c was studied in the mouse. H-2a and H-2k strains were responders to this antigen whereas H-2b, H-2d, H-2f, H-2ja, H-2p, H-2q, H-2r, H-2s, and H-2u strains were low or nonresponders. Genetic mapping demonstrated that two major histocompatibility complex (MHC)-linked Ir genes control the response, one in I-A, the other in I-E/I-C. The major antigenic determinant recognized in this response was localized by cross-stimulations with… CONTINUE READING

4 Figures & Tables

Connections & Topics

Mentioned Connections BETA
Tobacco hornworm moth cytochrome c , which contains a glutamine at residue 100 but a terminal lysine at residue 103 ( one amino acid closer to the glutamine ) , stimulated pigeon cytochrome c immune T cells better than the immunogen .
Tobacco hornworm moth cytochrome c , which contains a glutamine at residue 100 but a terminal lysine at residue 103 ( one amino acid closer to the glutamine ) , stimulated pigeon cytochrome c immune T cells better than the immunogen .
Amino AcidsChemical structure ofGlutamic Acid
Tobacco hornworm moth cytochrome c , which contains a glutamine at residue 100 but a terminal lysine at residue 103 ( one amino acid closer to the glutamine ) , stimulated pigeon cytochrome c immune T cells better than the immunogen .
Tobacco hornworm moth cytochrome c , which contains a glutamine at residue 100 but a terminal lysine at residue 103 ( one amino acid closer to the glutamine ) , stimulated pigeon cytochrome c immune T cells better than the immunogen .
c. It was found to be a topographic surface determinant composed of an isoleucine for valine substitution at residue 3 , a glutamine for lysine substitution at residue 100 and a lysine for glutamic acid substitution at residue 104 .
c. It was found to be a topographic surface determinant composed of an isoleucine for valine substitution at residue 3 , a glutamine for lysine substitution at residue 100 and a lysine for glutamic acid substitution at residue 104 .
c. It was found to be a topographic surface determinant composed of an isoleucine for valine substitution at residue 3 , a glutamine for lysine substitution at residue 100 and a lysine for glutamic acid substitution at residue 104 .
c. It was found to be a topographic surface determinant composed of an isoleucine for valine substitution at residue 3 , a glutamine for lysine substitution at residue 100 and a lysine for glutamic acid substitution at residue 104 .
c. It was found to be a topographic surface determinant composed of an isoleucine for valine substitution at residue 3 , a glutamine for lysine substitution at residue 100 and a lysine for glutamic acid substitution at residue 104 .
c. It was found to be a topographic surface determinant composed of an isoleucine for valine substitution at residue 3 , a glutamine for lysine substitution at residue 100 and a lysine for glutamic acid substitution at residue 104 .
c. It was found to be a topographic surface determinant composed of an isoleucine for valine substitution at residue 3 , a glutamine for lysine substitution at residue 100 and a lysine for glutamic acid substitution at residue 104 .
c. It was found to be a topographic surface determinant composed of an isoleucine for valine substitution at residue 3 , a glutamine for lysine substitution at residue 100 and a lysine for glutamic acid substitution at residue 104 .
c. It was found to be a topographic surface determinant composed of an isoleucine for valine substitution at residue 3 , a glutamine for lysine substitution at residue 100 and a lysine for glutamic acid substitution at residue 104 .
c. It was found to be a topographic surface determinant composed of an isoleucine for valine substitution at residue 3 , a glutamine for lysine substitution at residue 100 and a lysine for glutamic acid substitution at residue 104 .
Tobacco hornworm moth cytochrome c , which contains a glutamine at residue 100 but a terminal lysine at residue 103 ( one amino acid closer to the glutamine ) , stimulated pigeon cytochrome c immune T cells better than the immunogen .
Tobacco hornworm moth cytochrome c , which contains a glutamine at residue 100 but a terminal lysine at residue 103 ( one amino acid closer to the glutamine ) , stimulated pigeon cytochrome c immune T cells better than the immunogen .
LysineNo subtypeValine
c. It was found to be a topographic surface determinant composed of an isoleucine for valine substitution at residue 3 , a glutamine for lysine substitution at residue 100 and a lysine for glutamic acid substitution at residue 104 .
c. It was found to be a topographic surface determinant composed of an isoleucine for valine substitution at residue 3 , a glutamine for lysine substitution at residue 100 and a lysine for glutamic acid substitution at residue 104 .
ValineNo subtypeLysine
c. It was found to be a topographic surface determinant composed of an isoleucine for valine substitution at residue 3 , a glutamine for lysine substitution at residue 100 and a lysine for glutamic acid substitution at residue 104 .
c. It was found to be a topographic surface determinant composed of an isoleucine for valine substitution at residue 3 , a glutamine for lysine substitution at residue 100 and a lysine for glutamic acid substitution at residue 104 .
c. It was found to be a topographic surface determinant composed of an isoleucine for valine substitution at residue 3 , a glutamine for lysine substitution at residue 100 and a lysine for glutamic acid substitution at residue 104 .
c. It was found to be a topographic surface determinant composed of an isoleucine for valine substitution at residue 3 , a glutamine for lysine substitution at residue 100 and a lysine for glutamic acid substitution at residue 104 .
c. It was found to be a topographic surface determinant composed of an isoleucine for valine substitution at residue 3 , a glutamine for lysine substitution at residue 100 and a lysine for glutamic acid substitution at residue 104 .
c. It was found to be a topographic surface determinant composed of an isoleucine for valine substitution at residue 3 , a glutamine for lysine substitution at residue 100 and a lysine for glutamic acid substitution at residue 104 .
This fragment primed for a T - cell proliferative response whose specificity was nearly identical to that of the T - cell response primed for by the whole molecule , suggesting that the glutamine at 100 and the lysine at 104 form the immunodominant portion of the antigenic site .
Tobacco hornworm moth cytochrome c , which contains a glutamine at residue 100 but a terminal lysine at residue 103 ( one amino acid closer to the glutamine ) , stimulated pigeon cytochrome c immune T cells better than the immunogen .
Tobacco hornworm moth cytochrome c , which contains a glutamine at residue 100 but a terminal lysine at residue 103 ( one amino acid closer to the glutamine ) , stimulated pigeon cytochrome c immune T cells better than the immunogen .
c. It was found to be a topographic surface determinant composed of an isoleucine for valine substitution at residue 3 , a glutamine for lysine substitution at residue 100 and a lysine for glutamic acid substitution at residue 104 .
c. It was found to be a topographic surface determinant composed of an isoleucine for valine substitution at residue 3 , a glutamine for lysine substitution at residue 100 and a lysine for glutamic acid substitution at residue 104 .
This fragment primed for a T - cell proliferative response whose specificity was nearly identical to that of the T - cell response primed for by the whole molecule , suggesting that the glutamine at 100 and the lysine at 104 form the immunodominant portion of the antigenic site .
Tobacco hornworm moth cytochrome c , which contains a glutamine at residue 100 but a terminal lysine at residue 103 ( one amino acid closer to the glutamine ) , stimulated pigeon cytochrome c immune T cells better than the immunogen .
c. It was found to be a topographic surface determinant composed of an isoleucine for valine substitution at residue 3 , a glutamine for lysine substitution at residue 100 and a lysine for glutamic acid substitution at residue 104 .
c. It was found to be a topographic surface determinant composed of an isoleucine for valine substitution at residue 3 , a glutamine for lysine substitution at residue 100 and a lysine for glutamic acid substitution at residue 104 .
Tobacco hornworm moth cytochrome c , which contains a glutamine at residue 100 but a terminal lysine at residue 103 ( one amino acid closer to the glutamine ) , stimulated pigeon cytochrome c immune T cells better than the immunogen .
c. It was found to be a topographic surface determinant composed of an isoleucine for valine substitution at residue 3 , a glutamine for lysine substitution at residue 100 and a lysine for glutamic acid substitution at residue 104 .
c. It was found to be a topographic surface determinant composed of an isoleucine for valine substitution at residue 3 , a glutamine for lysine substitution at residue 100 and a lysine for glutamic acid substitution at residue 104 .
c. It was found to be a topographic surface determinant composed of an isoleucine for valine substitution at residue 3 , a glutamine for lysine substitution at residue 100 and a lysine for glutamic acid substitution at residue 104 .
c. It was found to be a topographic surface determinant composed of an isoleucine for valine substitution at residue 3 , a glutamine for lysine substitution at residue 100 and a lysine for glutamic acid substitution at residue 104 .
Tobacco hornworm moth cytochrome c , which contains a glutamine at residue 100 but a terminal lysine at residue 103 ( one amino acid closer to the glutamine ) , stimulated pigeon cytochrome c immune T cells better than the immunogen .
Tobacco hornworm moth cytochrome c , which contains a glutamine at residue 100 but a terminal lysine at residue 103 ( one amino acid closer to the glutamine ) , stimulated pigeon cytochrome c immune T cells better than the immunogen .
All Topics